Thiosemicarbazide is the chemical compound with the formula H2NC(S)NHNH2. A white, odorless solid, it is related to thiourea (H2NC(S)NH2) by the insertion of an NH center. They are commonly used as ligands for transition metals.[2] Many thiosemicarbazides are known. These feature an organic substituent in place of one or more H's of the parent molecule. 4-Methyl-3-thiosemicarbazide is a simple example.

A simple thiosemicarbazide-based chemodosimeter was employed to detect Ce4+ ion through turn-on fluorescence. The sensing mechanism was based on oxidative cyclization. The chemodosimeter exhibited exceptional selectivity for Ce4+, which allowed the detection of as low as 11 nM Ce4+ ion in an aqueous ethanol medium.

THIOSEMICARBAZIDE AR