Bis(trimethylsilyl)acetamide (BSA) is an organosilicon compound with the formula Me3SiNC(OSiMe3)Me (Me = CH3). It is a colorless liquid that is soluble in diverse organic solvents, but reacts rapidly with compounds, including solvents and moisture, containing OH and NH functional groups.

N, O-bis(trimethylsilyl)acetamide (BSA) is neutral silane protective agent, mainly used for the protection of amino acids, carboxylic acids, alcohols and amides. Meanwhile, BSA is used in passivation of chromatographic carriers and modification of polar groups of samples

It is used in analytical chemistry for the derivatisation of compounds in analysis to increase their volatility, e.g. for gas chromatography. It is also used to introduce the trimethylsilyl protecting group in organic synthesis. A related reagent is N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA).

NO BI STRIMETHYLSILYL ACETAMIDE BSA FOR SYNTHESIS