Ethyl trifluoroacetate is used as an intermediate in organic synthesis to prepare organic fluorine compounds like 3-ethyl-1-methylimidazolium trifluoroacetate (EMITA). It is involved in the syntheses of various pharmaceutically active molecules and agricultural products.

1. Ethyl trifluoroacetate can be used:
   • To synthesize cyclopentenones or furans containing trifluoromethyl group from aromatic ynones.
   • In the selective trifluoroacetylation of anilines catalyzed by 4-dimethylaminopyridine.
   • As a starting material in the two-step electrosynthesis of trifluoroacetyltrimethylsilane (CF₃COSiMe₃).
   • In the preparation of trifluoromethyl ketones via trifluoroacetic ester/ketone metathesis with alkyl aryl ketones.
   • To synthesize o-fluorinated trifluoro acetophenones from substituted fluorobenzene.

1. Moisture Sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents, strong bases and strong acids.

ETHYL TRIFLUORO ACETATE